Is 2,3,7,8-TCDD (Dioxin) a Carcinogen for Humans?
نویسندگان
چکیده
منابع مشابه
Is 2,3,7,8-TCDD (dioxin) a carcinogen for humans?
2,3,7,8-Tetrachlorodibenzo-p-dioxin (TCDD) has suddenly become the focal point of controversy over the relationship of chemical waste to human health. Specific concern exists regarding its potential association with human malignancy. Subcellular, cellular, and whole-animal experiments suggest that TCDD exerts much of its activity by inducing enzymes that protect the intact organism from the ass...
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Introduction EPA Methods 1613 (Tetrathrough Octa-Chlorinated Dioxins and Furans by Isotope Dilution HRGC/HRMS) and 8290a [Polychlorinated Dibenzodioxins(PCDDs) and Polychlorinated Dibenzofurans (PCDFs) By High Resolution Gas Chromatography/High Resolution Mass Spectrometry (HRGC/HRMS)] specify the use of a 60m 5% diphenyl 95% dimethyl polysiloxane GC column (e.g. DB-5, Rxi-5ms) for 2378 TCDD is...
متن کاملTCDD carcinogenicity in humans.
TCDD Carcinogenicity in Humans In volume 99 of EHP, Johnson gives his views of tetrachlorodibenzo-p-dioxin (TCDD) carcinogenicity in humans (1). The same topic was covered one year earlier by the same author in another journal (2). In regard to our studies (3-9), Johnson unfortunately repeats some misinterpretations of our results in both papers. I already commented on one of Johnson's earlier ...
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2,3,7,8-Tetrachlorodibenzo-p-dioxin (TCDD) is an extraordinarily toxic substance that is produced as an unwanted side product in the industrial synthesis of 2,4,5-trichlorophenol, an intermediate in the manufacture of the herbicide 2,4,5-trichlorophenoxyacetic acid (2,4,5-T) (1, 2). Because of its chemical stability and its lipophilic nature, the possibility exists that TCDD released into the e...
متن کاملQuantitative cancer risk assessments for 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD).
State-of-the-art quantitative risk assessment techniques, including consideration of new time-to-response data, have been applied to chronic animal bioassay data on the dietary intake of 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD). The non-linear shapes of the dose-response relationships for the hepatocellular carcinogenic responses have been estimated, and a review of the quantitative impacts o...
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ژورنال
عنوان ژورنال: Environmental Health Perspectives
سال: 1985
ISSN: 0091-6765
DOI: 10.2307/3430133